新冠病毒S蛋白突变|英国南非巴西突变|SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H65
产品名称： 新冠病毒S蛋白突变|英国南非巴西突变|SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H65
英文名称： SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified)
产品编号： SPN-C52Hg
产品价格： 0
产品产地： USA
品牌商标： ACROBiosystems
更新时间： null
使用范围： null
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SARS-CoV-2 S protein, His Tag (SPN-C52Hg) is the ectodomain of SARS-CoV-2 S protein that contains AA Val 16 - Pro 1213 (Accession # QHD43416.1) and mutations, which have become increasingly common in SARS-CoV-2 viruses from around the world. The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively. L18F/ T20N/ P26S/ D138Y/ R190S/ K417T/ E484K/ N501Y/ D614G/ H655Y/ T1027I/ V1176F mutations were identified in the SARS-CoV-2 variant (known as variant P.1) which emerged in the Brazil.
Molecular Characterization
Molecular Weight:
138.1 kDaPurity:
>95% as determined by SDS-PAGE.Endotoxin:
Less than 1.0 EU per μg by the LAL method.Bioactivity:
