EDG6,内皮细胞的分化蛋白6抗体

产品编号HZ-2883R
英文名称EDG6
中文名称内皮细胞的分化蛋白6抗体
别 名Endothelial differentiation lysophosphatidic acid G protein coupled receptor 6; Endothelial differentiation G protein coupled receptor 6; Endothelial differentiation gene 6; LPC1; Lysophospholipid receptor C1; MGC129298; Putative G protein coupled receptor; S1P receptor 4; S1P receptor Edg6; S1P4; S1PR4; SLP4; Sphingosine 1 phosphate receptor 4; Sphingosine 1 phosphate receptor Edg6; S1PR4_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 转录调节因子 细胞膜受体 内皮细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Horse,
EDG6,内皮细胞的分化蛋白6抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:20-100 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EDG6/SLP4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EDG6,内皮细胞的分化蛋白6抗体PubMedPubMed
产品介绍background:
This protein belongs to a G protein coupled heptahelical receptor subfamily named Endothelial Cell Differentiation Genes (EDG)that act as receptors for biologically active lysophospholipids. This group consists of two receptor subgroups specific for S1P and LPA respectively. EDG6 is the receptor for lysophospholipid sphingosine 1 phosphate (S1P). S1P elicits diverse physiological effect on most types of cells and tissues. EDG6 may be involved in cell migration processes that are specific for lymphocytes.

Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Gene ID:
8698

EDG6,内皮细胞的分化蛋白6抗体Database links:
Entrez Gene: 8698 Human
Entrez Gene: 13611 Mouse
Omim: 603751 Human
SwissProt: O95977 Human
SwissProt: Q9Z0L1 Mouse
Unigene: 662006 Human
Unigene: 33065 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.