FITC标记的G蛋白偶联受体GPR161蛋白抗体
产品名称： FITC标记的G蛋白偶联受体GPR161蛋白抗体
英文名称： Anti-GPR161/FITC
产品编号： HZ-15385R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPR161/FITC Conjugated antibody
FITC标记的G蛋白偶联受体GPR161蛋白抗体
| 英文名称 | Anti-GPR161/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体GPR161蛋白抗体 |
| 别 名 | FLJ33952; G-protein coupled receptor 161; G-protein coupled receptor RE2; GP161; GPR161; RE2; GP161_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR161 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G-protein coupled receptors translate extracellular signals into intracellular signals (G-protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR161 (G protein-coupled receptor 161), also known as RE2, is a 529 amino acid protein that belongs to the G-protein coupled receptor family. Localized to the cell membrane, GPR161 is a multi-pass membrane protein that functions as an orphan receptor, relaying extracellular signals to the intracellular environment. Two isoforms of GPR161 exist due to alternative splicing events. Function: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). Subcellular Location: Cell projection, cilium membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 23432 Human Entrez Gene: 240888 Mouse SwissProt: Q8N6U8 Human SwissProt: B2RPY5 Mouse Unigene: 271809 Human Unigene: 329929 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
G蛋白偶联受体(GPR)又称七种跨膜受体、七肽受体或七肽甲基转移酶(7TM)受体，由在许多不同的刺激-反应途径中起作用的蛋白超家族组成。G-蛋白偶联受体将细胞外信号翻译成细胞内信号(G-蛋白激活)，并对多种信号分子作出反应，如激素和神经递质。GPR161(G蛋白偶联受体161)，又称RE2，是属于G蛋白偶联受体家族的529个氨基酸蛋白。定位于细胞膜，GPR161是一种多功能膜蛋白，作为孤儿受体发挥作用，将胞外信号传递给细胞内环境。GPR161的两种异构体由于选择性剪接事件而存在。