ELL,聚合酶延伸因子抗体

产品编号HZ-8515R
英文名称ELL
中文名称聚合酶延伸因子抗体
别 名ELL_HUMAN; Eleven nineteen lysine rich leukemia gene; Eleven-nineteen lysine-rich leukemia protein; ELL1; elongation factor RNA polymerase II; Men; RNA polymerase II elongation factor; RNA polymerase II elongation factor ELL.
说 明 书0.1ml 0.2ml
研究领域细胞生物 染色质和核信号 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse,
ELL,聚合酶延伸因子抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ELL
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ELL,聚合酶延伸因子抗体PubMedPubMed
产品介绍background:
Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein), also designated MEN, functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. It is also thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, with lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes that undergo translocation with the MLL gene on chromosome 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia, also designated ALL-1 and HRX) regulates embryonal and hematopoietic development.

Subunit:
Interacts with EAF1 and EAF2.

Subcellular Location:
Nuclear. Colocalizes with EAF2 to nuclear speckles and to Cajal bodies.

ELL,聚合酶延伸因子抗体Tissue Specificity:
Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.

Post-translational modifications:

DISEASE:

Similarity:
Belongs to the ELL/occludin family.

Gene ID:
8178

Database links:
Entrez Gene: 8178 Human
Entrez Gene: 13716 Mouse
Omim: 600284 Human
SwissProt: P55199 Human
SwissProt: O08856 Mouse
SwissProt: Q3TXY9 Mouse
Unigene: 515260 Human
Unigene: 271973 Mouse

ELL,聚合酶延伸因子抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.