FITC标记的细胞增殖诱导蛋白5/肺癌相关蛋白10抗体
产品名称： FITC标记的细胞增殖诱导蛋白5/肺癌相关蛋白10抗体
英文名称： Anti-MAEA/FITC
产品编号： HZ-12337R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MAEA/FITC Conjugated antibody
FITC标记的细胞增殖诱导蛋白5/肺癌相关蛋白10抗体
| 英文名称 | Anti-MAEA/FITC |
| 中文名称 | FITC标记的细胞增殖诱导蛋白5/肺癌相关蛋白10抗体 |
| 别 名 | 1110030D19Rik; Cell proliferation inducing gene 5 protein; Cell proliferation-inducing gene 5 protein; EMP; Erythroblast macrophage protein; HLC 10; HLC-10; HLC10; Human lung cancer oncogene 10 protein; Lung cancer related protein 10; lung cancer-related protein 10; Macrophage erythroblast attacher; MAEA; MAEA_HUMAN; MGC93683; PIG5; proliferation-inducing gene 5. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 发育生物学 干细胞 细胞凋亡 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAEA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Emp is a 396 amino acid ubiquitously expressed adhesion protein. Expressed as 5 alternatively spliced isoforms, Emp contains one CTLH domain and one LisH domain. Emp can form a complex with F-actin, which is involved regulating actin distribution in erythroblasts and macrophages. Considered to assist with cell division and nuclear architecture, Emp is localized with condensed chromatin at prophase, nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis. Although the exact function of Emp is unknown, Emp is suggested to be involvement in erythroblast-macrophage cell attachment, terminal maturation and enucleation of erythroid cells, and inhibiting apoptosis of erythroblasts. Function: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. Subunit: Forms a complex with F-actin. Subcellular Location: Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern. Tissue Specificity: Ubiquitous. Similarity: Contains 1 CTLH domain. Contains 1 LisH domain. Database links: Entrez Gene: 10296 Human Entrez Gene: 59003 Mouse Entrez Gene: 298982 Rat Entrez Gene: 426024 Chicken Entrez Gene: 511956 Cow Omim: 606801 Huma SwissProt: Q5F398 Chicken SwissProt: Q3MHJ2 Cow SwissProt: Q7L5Y9 Human SwissProt: Q4VC33 Mouse SwissProt: Q5RKJ1 Rat Unigene: 139896 Human Unigene: 281642 Mouse Unigene: 101181 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
EMP是396个氨基酸普遍表达的粘附蛋白。表示为5个交替拼接的异构体，EMP包含一个CTLH域和一个英文域。EMP可与F-肌动蛋白形成复合物，参与调节红细胞和巨噬细胞中肌动蛋白的分布。EMP在细胞分裂和核结构中起着重要作用，EMP定位于前期的凝集染色质、中期的核纺锤体极点和终末期和胞质分裂中的收缩环。虽然EMP的确切功能尚不清楚，但Emp建议参与红细胞巨噬细胞的附着、终末成熟和红细胞的去核，以及抑制红细胞的凋亡。