SEPT12,细胞分化蛋白SEPT12抗体

产品编号HZ-7771R
英文名称SEPT12
中文名称细胞分化蛋白SEPT12抗体
别 名SEPT12; SEPT 12; SEP12_HUMAN; Septin-12; Septin 12; Septin12.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 细胞分化 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Zebrafish
SEPT12,细胞分化蛋白SEPT12抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SEPT12
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SEPT12,细胞分化蛋白SEPT12抗体PubMedPubMed
产品介绍background:
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis.

Function:
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Subunit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT6 and SEPT11. Forms homodimers.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection, cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus.

Tissue Specificity:
Widely expressed.

SEPT12,细胞分化蛋白SEPT12抗体DISEASE:
Defects in SEPT12 are the cause of spermatogenic failure 10 (SPGF10) [MIM:614822]. An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal piece of the sperm tail.

Similarity:
Belongs to the septin family.

Gene ID:
124404

Database links:
Entrez Gene: 124404 Human
Entrez Gene: 71089 Mouse
Entrez Gene: 363542 Rat
Omim: 611562 Human
SwissProt: Q8IYM1 Human
SwissProt: Q4V8G5 Rat
Unigene: 126780 Human
Unigene: 123511 Rat

SEPT12,细胞分化蛋白SEPT12抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SEPTIN(SEPT)家族是细胞骨架蛋白的一种，具有GTPase的活性。经研究发現，SEPT参与细胞核分裂、细胞膜的运输以及构成细胞骨架。