BAGE2 + BAGE3,肿瘤/睾丸抗原2.2/睾丸抗原2.3抗体

产品编号bs-9114R
英文名称BAGE2 + BAGE3
中文名称肿瘤/睾丸抗原2.2/睾丸抗原2.3抗体
别 名B melanoma antigen 2; B melanoma antigen family, member 2; Cancer/testis antigen 2.2; CT2.2; BAGE2_HUMAN; B melanoma antigen family member 3; B melanoma antigen 3; BAGE3; BAGE3_HUMAN; Cancer/testis antigen 2.3; Cancer/testis antigen family 2 member 3; CT2.3.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
BAGE2 + BAGE3,肿瘤/睾丸抗原2.2/睾丸抗原2.3抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BAGE2 and BAGE2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BAGE2 + BAGE3,肿瘤/睾丸抗原2.2/睾丸抗原2.3抗体PubMedPubMed
产品介绍background:
Members of the BAGE gene family encode antigens that are recognized by cytotoxic T lymphocytes and are also known as CT (cancer/testis) antigens. Generated by juxtacentromeric shuffling of the MLL3 gene, the ancestral BAGE gene was expanded by acrocentric exchanges and/or juxtacentromeric movements.Generally, BAGE proteins are silent in all normal tissues with the exception of testis. BAGE2 and BAGE 3 (B melanoma antigen 2 and 3, respectively), also known as Cancer/testis antigen 2.2 and 2.3 (respectively), are 109 amino acid secreted proteins that are expressed in 22% of melanomas, lung and bladder carcinomas, and are also expressed in normal testis tissue. Like the genes encoding MAGE proteins, BAGE genes are most likely silenced by DNA methylation and/or chromatin compaction in normal tissues other than testis.

Function:
Unknown. Candidate gene encoding tumor antigens.

Subcellular Location:
Secreted.

Tissue Specificity:
Not expressed in normal tissues except in testis. Expressed in 22% of melanomas, in bladder and lung carcinomas.

Similarity:
Belongs to the BAGE family.

Gene ID:
85319

BAGE2 + BAGE3,肿瘤/睾丸抗原2.2/睾丸抗原2.3抗体Database links:
Entrez Gene: 85319 Human
SwissProt: Q86Y30 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.