SOX4,核转录因子SOX4抗体

产品编号HZ-11208R
英文名称SOX4
中文名称核转录因子SOX4抗体
别 名SOX4; SOX 4; SOX-4; Ecotropic viral integration site 16; EVI 16; EVI16; SRY (sex determining region Y) box 4; SRY box containing gene 4; SRY related HMG box gene 4.
说 明 书0.1ml 0.2ml
研究领域神经生物学 干细胞 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken,
SOX4,核转录因子SOX4抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SOX4(54-103aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SOX4,核转录因子SOX4抗体PubMedPubMed
产品介绍background:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

Function:
The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate. SOX4 shows a high degree of sequence homology with SOX11. Both are expressed in the CNS. SOX4 and SOX11 expression increase together in the developing CNS (with some exceptions: external granule layer of the cerebellum). SOX4 knock-out mice have been shown to die of a heart defect half way through gestation with no observable CNS phenotype, although it has been proposed that SOX11 compensates for the absence of SOX4.

Subunit:
Interacts with UBE2I.

Subcellular Location:
Nuclear

SOX4,核转录因子SOX4抗体Tissue Specificity:
Testis, brain, and heart.

Similarity:
Contains 1 HMG box DNA-binding domain.

Database links:
Entrez Gene: 395143 Chicken
Entrez Gene: 768313 Cow
Entrez Gene: 6659 Human
Entrez Gene: 20677 Mouse
Entrez Gene: 364712 Rat
Entrez Gene: 336346 Zebrafish
Omim: 184430 Human
SwissProt: Q0VCF8 Cow
SwissProt: Q06945 Human
SwissProt: Q06831 Mouse
Unigene: 643910 Human
Unigene: 240627 Mouse
Unigene: 455819 Mouse
Unigene: 163667 Rat

SOX4,核转录因子SOX4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.