Anti-ABC2/FITC Conjugated抗体-抗体-抗体-生物在线
上海钰博生物科技有限公司
Anti-ABC2/FITC Conjugated抗体

Anti-ABC2/FITC Conjugated抗体

商家询价

产品名称： Anti-ABC2/FITC Conjugated抗体

英文名称： Anti-ABC2/FITC

产品编号： YB--6515R-FITC

产品价格： null

产品产地： 中国/美国

品牌商标： Ybscience

更新时间： 2023-08-17T10:29:50

使用范围： 科研使用

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 Anti-ABC2/FITC Conjugated抗体

产品编号 YB-6515R-FITC
英文名称 Anti-ABC2/FITC
中文名称 FITC标记的乳腺癌增强蛋白2抗体
别    名 ABC 2; ABC2; ABC-2; Amplified in breast cancer gene 2 protein; Chromosome 17 open reading; chromosome 17 open reading frame 71; Protein smg 8 homolog; protein SMG8; SMG8; SMG8 protein; SMG8_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  肿瘤细胞生物标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 110kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABC2/C17orf71 (744-790aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
C17orf71 belongs to the UPF0487 family. There are 3 isoforms produced by alternative splicing.Positive control;Human Anaplastic Thyroid Carcinoma, Human Breast Carcinoma.

Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. 

Subunit:
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Forms heterodimers with SMG9; this assembly form may represent a SMG1C intermediate form.

Subcellular Location:
Phosphorylated by SMG1

Post-translational modifications:
Phosphorylated by SMG1. 

Similarity:
Belongs to the SMG8 family. 

Database links:
 

UniProtKB/Swiss-Prot: Q8ND04.1



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications