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上海信裕生物科技有限公司
ATF6抗体

ATF6抗体

商家询价

产品名称： ATF6抗体

英文名称： ATF6Antibody

产品编号： XY24169-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 ATF6抗体

Applications
In-house applications ELISA, WB, IF, IHC, IP     Application not tested? Please see our Guarantee.
Published applications WB Publications 2 citations –view here
Species specificity Human, Rat, Mouse; other species not tested.
Published Species Human, rat
Images
Prev12NextView more validation data
  • 24169-1-AP;MCF-7 cellsMCF-7 cells were subjected to SDS PAGE followed by western blot with 24169-1-AP( ATF6 Antibody) at dilution of 1:3000
  • 24169-1-AP;HeLa cellsIP Result of anti-ATF6 (IP:24169-1-AP, 4ug; Detection:24169-1-AP 1:1500) with HeLa cells lysate 2800ug.
  • 24169-1-AP;human cervical cancer tissueImmunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 24169-1-AP( ATF6 Antibody) at dilution of 1:50 (under 40x lens)
  • 24169-1-AP;HeLa cellsImmunofluorescent analysis of HeLa cells using 24169-1-AP( ATF6 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
Positive WB detected in MCF-7 cells, HeLa cells, mouse liver tissue
Positive IP detected in HeLa cells
Positive IHC detected in Human cervical cancer tissue, human pancreas tissue
Positive IF detected in HeLa cells
Recommended dilution WB : 1:1000-1:10000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:10-1:100
 ATF6抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen Affinity purified
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen ATF6 fusion protein ag21456 Full name Activating transcription factor 6
Calculated molecular
weight		 75 kDa Observed molecular 
weight		 90 kDa
GenBank accession 
number		 BC014969 Gene ID (NCBI) 22926
Gene symbol ATF6 Synonyms ATF6, ATF6 alpha, ATF6A
Background ATF6抗体

Activating transcription factor 6 (ATF6) is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases. The fully glycosylated form of ATF6, a 670 amino acid protein, exhibits an electrophoretic mobility of ~90 kDa in denaturing SDS-gels, in part because of the glycosylated modifications. ATF6 has 3 consensus sites for N-linked glycosylation and exists constitutively as a glycosylated protein. Differentially glycosylated ATF6 forms may result from mutations or experimental treatment (PMID：15804611) (PMID:14699159). The antibody recognizes cleaved and fully glycosylated forms of ATF6. ATF6抗体

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