FITC标记的细胞表面趋化因子受体9抗体
产品名称： FITC标记的细胞表面趋化因子受体9抗体
英文名称： Anti-CCR9/FITC
产品编号： HZ-1788R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CCR9/FITC Conjugated antibody
FITC标记的细胞表面趋化因子受体9抗体
| 英文名称 | Anti-CCR9/FITC |
| 中文名称 | FITC标记的细胞表面趋化因子受体9抗体 |
| 别 名 | CCR-9; C C chemokine receptor D6; C C chemokine receptor type 9; C C CKR 9; CC Chemokine receptor CCR10; CC CKR 9; CCBP2; CCCKR9; CCR 9; CCR9; CDw199; CDw199 antigen; Chemokine C C motif receptor 9; Chemokine CC Motif Receptor 9; Chemokine receptor CCR 9; Chemokine-binding protein D6; CMKBR9; G protein coupled receptor 28; GPR 28; GPR 9 6; GPR28; GPR96; CCR9_HUMA. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCR9 (107-127aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. Two alternatively spliced transcript variants have been described. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in the thymus and low in lymph nodes and spleen. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 10803 Human Entrez Gene: 12769 Mouse Entrez Gene: 282832 Rat Omim: 604738 Human SwissProt: P51686 Human SwissProt: Q9WUT7 Mouse Unigene: 225946 Human Unigene: 91140 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
由该基因编码的蛋白质是β趋化因子受体家族的成员。它是一种类似于G蛋白偶联受体的七跨膜蛋白。趋化因子及其受体是正常和炎症条件下胸腺细胞迁移和成熟的关键调节因子。该基因在一系列组织和造血细胞中表达。该受体在淋巴管内皮细胞中的表达和在血管肿瘤中的过表达提示其在趋化因子驱动的白细胞再循环中的作用以及对血管肿瘤的发展和生长的可能趋化因子作用。这种受体似乎与大多数β-趋化因子家族成员结合，但其具体功能尚不清楚。该受体的特异性配体是CCL25。已发现该基因由小肠和结肠的T淋巴细胞差异表达，提示其在胸腺细胞的募集和发育中可能起作用，从而允许胃肠道不同部位的免疫应答的功能特异性。这个基因被定位到染色体3p21.3，这个区域包括一组趋化因子受体基因。已经描述了两种交替剪接转录变体。