Phospho-CEBP alpha (Thr222 + Thr226),磷酸化转录调节因子CEBP α 抗体

产品编号HZ-3061R
英文名称Phospho-CEBP alpha (Thr222 + Thr226)
中文名称磷酸化转录调节因子CEBP α 抗体
别 名CEBP Alpha (phospho T226); p-CEBP Alpha (phospho T226); CEBP Alpha (phospho T222); p-CEBP Alpha (phospho T222); Apoptotic cysteine protease; Apoptotic protease Mch 5; C/EBP alpha; CAP4; Caspase 8 precursor; CCAAT Enhancer Binding Protein alpha; CEBP; CEBP A; CEBP alpha; CEBPA; FADD homologous ICE/CED 3 like protease; FADD like ICE; FLICE; ICE like apoptotic protease 5; ICE8; MACH; MCH5; MORT1 associated CED 3 homolog; CEBPA_HUMAN.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域细胞生物 免疫学 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
Phospho-CEBP alpha (Thr222 + Thr226),磷酸化转录调节因子CEBP α 抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human CEBP alpha around the phosphorylation site of Thr222/226
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Phospho-CEBP alpha (Thr222 + Thr226),磷酸化转录调节因子CEBP α 抗体PubMedPubMed
产品介绍background:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Mutations in this gene are frequently found in acute myeloid leukemia (AML).

Function:
C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

Subunit:
Interacts with PRDM16 (By similarity). Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X. Interacts with ZNF638; this interaction increases transcriptional activation.

Subcellular Location:
Nucleus.

Phospho-CEBP alpha (Thr222 + Thr226),磷酸化转录调节因子CEBP α 抗体Similarity:
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain.

Gene ID:
1050

Database links:
Entrez Gene: 1050 Human
Entrez Gene: 12606 Mouse
Entrez Gene: 24252 Rat
Omim: 116897 Human
SwissProt: P49715 Human
SwissProt: P53566 Mouse
SwissProt: P05554 Rat
Unigene: 76171 Human
Unigene: 349667 Mouse
Unigene: 153603 Rat
Unigene: 204833 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.