FITC标记的肺表面活性蛋白D抗体
产品名称： FITC标记的肺表面活性蛋白D抗体
英文名称： Anti-SFTPD/FITC
产品编号： HZ-1583R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-SFTPD/FITC Conjugated antibody
| FITC标记的肺表面活性蛋白D抗体 |
| 英文名称 | Anti-SFTPD/FITC |
| 中文名称 | FITC标记的肺表面活性蛋白D抗体 |
| 别 名 | SFTPD surfactant protein D; pulmonary surfactant-associated glycoprotein D; COLEC 7; COLEC7; Collectin7; PSP D; PSPD; Pulmonary surfactant apoprotein; Pulmonary surfactant associated protein D; SFTP 4; SFTP4; SFTPD; SP D; Surfactant associated protein pulmonary 4; Surfactant pulmonary associated protein D; SFTPD_HUMAN; Pulmonary surfactant-associated protein D; PSP-D; SP-D; Collectin-7; Lung surfactant protein D. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SP-D |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Surfactant protein D contributes to the lung's defense against inhaled microorganisms. It's a calcium ion dependent carbohydrate binding protein and is structurally similar to other C type mammalian lectins, such as conglutinin and SPA. It has a molecular size of approximately 37-43kDa in its reduced state, 620kDa in non dissociating conditions. Surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages and regulates some actions of SPA, which is the most abundant surfactant protein. Surfactant protein D is synthesized and secreted by alveolar epithelial type II cells. Function: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. Subunit: Oligomeric complex of 4 set of homotrimers. Subcellular Location: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. Post-translational modifications: The N-terminus is blocked. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. Similarity: Belongs to the SFTPD family. Contains 1 C-type lectin domain. Contains 1 collagen-like domain. Database links: Entrez Gene: 6441 Human Entrez Gene: 20390 Mouse Entrez Gene: 25350 Rat Omim: 178635 Human SwissProt: P35247 Human SwissProt: P50404 Mouse SwissProt: P35248 Rat Unigene: 253495 Human Unigene: 1321 Mouse Unigene: 11348 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
表面活性蛋白D有助于肺对吸入微生物的防御。它是一种钙离子依赖性的碳水化合物结合蛋白，其结构类似于其他C型哺乳动物凝集素，如凝集素和SPA。它的分子尺寸约为37.43kDa，其还原态为620kDa，在非解离条件下。表面活性蛋白D促进大鼠肺泡巨噬细胞产生氧自由基，并调节SPA的某些作用，SPA是最丰富的表面活性蛋白。肺泡上皮II型细胞合成并分泌表面活性蛋白D。