ATX3,ATXN3 抗体
Applications
| In-house applications |
ELISA, WB, IHC Application not tested? Please see our Guarantee. |
| Published applications |
IF, IP, WB |
Publications |
3 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Human, mouse |
|
Images
Prev1Next
 mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 13505-1-AP(ATX3,ATXN3 antibody) at dilution of 1:500 Immunohistochemical of paraffin-embedded human pancreas cancer using 13505-1-AP(ATX3,ATXN3 antibody) at dilution of 1:100 (under 10x lens) Immunohistochemical of paraffin-embedded human pancreas cancer using 13505-1-AP(ATX3,ATXN3 antibody) at dilution of 1:100 (under 40x lens)
|
| Positive WB detected in |
Mouse pancreas tissue, HEK-293 cells, mouse brain tissue, mouse heart tissue, mouse liver tissue, mouse placenta tissue |
| Positive IHC detected in |
Human pancreas cancer tissue |
| Recommended dilution |
WB : 1:200-1:2000
IHC : 1:20-1:200 |
ATX3,ATXN3 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
ATX3,ATXN3 fusion protein ag4341 |
Full name |
Ataxin 3 |
Calculated molecular
weight |
370aa,43 kDa |
Observed molecular
weight |
35-42 kDa |
GenBank accession
number |
BC033711 |
Gene ID (NCBI) |
4287 |
| Gene symbol |
ATXN3 |
Synonyms |
AT3, ataxin 3, ATX3, ATXN3, JOS, MJD, MJD1, SCA3 |
Background ATX3,ATXN3 抗体
|
ATXN3, which has deubiquitinase activity and act as a component of the ubiquitin proteasome system, plays a role in transcriptional regulation and neuroprotection. ATXN3 interacts with RAD23, HHR23A and HHR23B, involves in the pathology of MJD. ATXN3 is a mixed-linkage, chain-editing enzyme and that the UIM region of ATXN3 regulates its substrate specificity. Contains an N-terminal deubiquitinating domain, called the Josephin domain, followed by 2 ubiquitin-interacting motifs (UIMs) and a polyQ tract near the C terminus. ATXN3 can be phosphorylated in a protein casein kinase-2-dependent manner, thus the MW would be larger than the predicted one. ATX3,ATXN3 抗体
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