NR2E1,核受体蛋白NR2E1抗体

产品编号HZ-11202R
英文名称NR2E1
中文名称核受体蛋白NR2E1抗体
别 名NR2E1 / Tailless; Tailless; hTll; nr2e1; NR2E1_HUMAN; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Orphan nuclear receptor NR2E1; Protein tailless homolog; Tailless homolog; Tll; TLX; XTLL.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 干细胞 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,
NR2E1,核受体蛋白NR2E1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NR2E1/Tailless
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NR2E1,核受体蛋白NR2E1抗体PubMedPubMed
产品介绍background:
NR2 proteins are a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E1 (nuclear receptor subfamily 2, group E, member 1), also known as TLX, is an essential component in the formation of synaptic plasticity and dendritic structure in retinal astrocytes. In addition, NR2E1 is a orphan receptor that binds DNA as part of the hormone response element (HRE), a transcription regulator for hormones. DNA-binding orphan receptors have the conserved sequence 5'-AAGGTCA-3', a motif that determines substrate binding specificity. NR2E1 is expressed in brain tissue, with highest levels in astrocytes, and is localized to the nucleus. Mutations in the gene that encodes NR2E1 may lead to retinal dystrophy, a disorder characterized by a reduction in the thickness of the retina.

Function:
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development.

Subunit:
Monomer (By similarity). Interacts with ATN1; the interaction represses the transcription

Subcellular Location:
Nucleus.

Tissue Specificity:
Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.

Similarity:
Belongs to the nuclear hormone receptor family. NR2 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Gene ID:
7101

Database links:
Entrez Gene: 7101 Human
Entrez Gene: 396082 Chicken
Entrez Gene: 21907 Mouse
Entrez Gene: 684085 Rat
Omim: 603849 Human
SwissProt: Q91379 Chicken
SwissProt: Q9Y466 Human
SwissProt: Q3UXE8 Mouse
SwissProt: Q64104 Mouse
SwissProt: Q78ZM1 Mouse
SwissProt: P70052 Xenopus laevis
SwissProt: Q6DEH0 Zebrafish
Unigene: 157688 Human
Unigene: 287100 Mouse
Unigene: 1067 Xenopus laevis

NR2E1,核受体蛋白NR2E1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.