OTX1,转录因子OTX1抗体

产品编号HZ-11596R
英文名称OTX1
中文名称转录因子OTX1抗体
别 名Homeobox protein OTX 1; Homeobox protein OTX1; MGC15736; Orthodenticle 1; Orthodenticle homeobox 1; Orthodenticle homolog 1; Orthodenticle1; Otx 1; otx1; OTX1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
OTX1,转录因子OTX1抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human OTX1 (1-100aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
OTX1,转录因子OTX1抗体PubMedPubMed
产品介绍background:
Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p15 and 14q21-q22, respectively.

Function:
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in brain.

Similarity:
Belongs to the paired homeobox family. Bicoid subfamily.
Contains 1 homeobox DNA-binding domain.

Gene ID:
5013

OTX1,转录因子OTX1抗体Database links:
Entrez Gene: 5013 Human
Entrez Gene: 18423 Mouse
Entrez Gene: 25646 Rat
Omim: 600036 Human
SwissProt: P32242 Human
SwissProt: Q53TG6 Human
SwissProt: P80205 Mouse
SwissProt: Q5SS54 Mouse
SwissProt: Q91ZJ3 Mouse
SwissProt: Q63410 Rat
Unigene: 445340 Human
Unigene: 129663 Mouse
Unigene: 33443 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.