VE Cadherin,上皮型钙粘附分子抗体

产品编号HZ-4310R
英文名称VE Cadherin
中文名称上皮型钙粘附分子抗体
别 名VE-cadherin; cadherin-5; VE-Cadherin;Cdh5; Vascular endothelial cadherin; 7B4 antigen; CD144 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; Vascular epithelium cadherin; VE Cad antibody VE-cadherin; VE cadherin; VEC; CADH5_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 细胞生物 信号转导 细胞粘附分子 血管内皮细胞 内皮细胞 细胞骨架 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse,
VE Cadherin,上皮型钙粘附分子抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human VE Cadherin (251-320aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
VE Cadherin,上皮型钙粘附分子抗体PubMedPubMed
产品介绍background:
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].

Function:
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.

Subunit:
Interacts via cadherin 5 domain with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1.

Subcellular Location:
Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.

Tissue Specificity:
Endothelial tissues and brain.

Post-translational modifications:
Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.

Similarity:
Contains 5 cadherin domains.

Gene ID:
1003

VE Cadherin,上皮型钙粘附分子抗体Database links:
Entrez Gene: 1003 Human
Entrez Gene: 12562 Mouse
Entrez Gene: 307618 Rat
Omim: 601120 Human
SwissProt: P33151 Human
SwissProt: P55284 Mouse
Unigene: 76206 Human
Unigene: 21767 Mouse
Unigene: 224644 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.