FITC标记的ras癌基因家族Rab11蛋白抗体
产品名称： FITC标记的ras癌基因家族Rab11蛋白抗体
英文名称： Anti-Rab11/FITC
产品编号： HZ-6173R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Rab11/FITC Conjugated antibody
| FITC标记的ras癌基因家族Rab11蛋白抗体 |
| 英文名称 | Anti-Rab11/FITC |
| 中文名称 | FITC标记的ras癌基因家族Rab11蛋白抗体 |
| 别 名 | MGC1490; Rab 11; Rab 11A; RAB 11A member oncogene family; RAB 11A, member oncogene family; Rab-11; RAB11 A; RAB11; RAB11A; RAB11A member RAS oncogene family; Ras related protein Rab 11A; Ras related protein Rab11A; Ras-related protein Rab-11A; RB11A_HUMAN; YL 8; YL8. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Rab11 (75-117aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There are over 40 Rab proteins in mammals. Rab11a and Rab11b are known markers for protein trafficking, sorting, and recycling in the endosomal pathway. The Rab11 proteins are enriched in recycling endosomes and the trans-Golgi network, where they regulate membrane recycling back to the plasma membrane. Rab11a is ubiquitously expressed, while Rab11b is expressed mainly in the heart and brain. Function: Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). Subunit: Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SPE39//C14orf133. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. Subcellular Location: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis. Similarity: Belongs to the small GTPase superfamily. Rab family. Database links: Entrez Gene: 415544 Chicken Entrez Gene: 534708 Cow Entrez Gene: 403957 Dog Entrez Gene: 8766 Human Entrez Gene: 53869 Mouse Entrez Gene: 100009072 Rabbit Entrez Gene: 81830 Rat Entrez Gene: 447589 Xenopus laevis Entrez Gene: 492487 Zebrafish Omim: 605570 Human SwissProt: Q5ZJN2 Chicken SwissProt: Q2TA29 Cow SwissProt: P62490 Dog SwissProt: P62491 Human SwissProt: P62492 Mouse SwissProt: Q52NJ1 Pig SwissProt: P62493 Rabbit SwissProt: P62494 Rat Unigene: 321541 Human Unigene: 1387 Mouse Unigene: 1016 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
RAB蛋白是低分子量的GTP结合蛋白，是GTPs的Ras超家族的最大分支。Rb蛋白位于细胞器和囊泡的细胞质表面，参与细胞内膜融合反应。三个膜蛋白，突触体相关蛋白25 kDa（SNAP-25），突触蛋白和突触结合蛋白，是一个无处不在的膜融合机的核心，与可溶性蛋白N-乙基马来酰亚胺敏感因子（NSF）和A- SNAP相互作用。RAB蛋白与核心融合机制和MUNC-18协同，有助于介导囊泡的对接和融合。哺乳动物中存在超过40个RAB蛋白。Rab11a和Rab11b是已知的蛋白质内运输、分类和回收的标记物。Rab11蛋白富集在循环内涵体和反高尔基网络中，在那里它们调节膜循环回到质膜。Rab11a是广泛表达的，而Rab11b主要在心脏和脑中表达。