Collagen IX,胶原蛋白9抗体

产品编号HZ-13962R
英文名称Collagen IX
中文名称胶原蛋白9抗体
别 名Collagen alpha 1(IX) chain; Collagen type IX alpha 1; EDM6; MED; STL4.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
Collagen IX,胶原蛋白9抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量89kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Collagen IX
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Collagen IX,胶原蛋白9抗体PubMedPubMed
产品介绍background:
Type IX collagen proteoglycan is a major component of hyaline cartilages where it is located on the surface of the collagen fibrils so that a collagenous domain of the molecule (called COL 3) and a non-collagenous domain (called NC4) project at periodic distances away from the surface of the fibrils.

Function:
Structural component of hyaline cartilage and vitreous of the eye.

Subunit:
Heterotrimer of an alpha 1(IX), an alpha 2(IX) and an alpha 3(IX) chain.

Subcellular Location:
Secreted, extracellular space, extracellular matrix (By similarity).

Tissue Specificity:
Cytoplasmic

Post-translational modifications:
Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

DISEASE:
Multiple epiphyseal dysplasia 6 (EDM6) [MIM:614135]: A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. Note=The disease is caused by mutations affecting the gene represented in this entry.

Collagen IX,胶原蛋白9抗体Similarity:
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
Contains 10 collagen-like domains.
Contains 1 laminin G-like domain.

Gene ID:
1297

Database links:
Entrez Gene: 1297 Human
Entrez Gene: 12839 Mouse
Entrez Gene: 305104 Rat
Omim: 120210 Human
SwissProt: P20849 Human
SwissProt: Q05722 Mouse
SwissProt: P20850 Rat
Unigene: 590892 Human
Unigene: 154662 Mouse
Unigene: 90726 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.