分子量:26.1 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Biotinylated Human B7-H4 by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Biotinylated Human B7-H4 Protein  has a calculated MW of 26.1 kDa. The predicted N-terminus is Phe 29. As a result of glycosylation, the reducing (R) protein migrates as 43-60 kDa in SDS-PAGE.

产品背景:V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.