Anti-FBXW12/FITC Conjugated抗体-抗体-抗体-生物在线
上海钰博生物科技有限公司
Anti-FBXW12/FITC Conjugated抗体

Anti-FBXW12/FITC Conjugated抗体

商家询价

产品名称： Anti-FBXW12/FITC Conjugated抗体

英文名称： Anti-FBXW12/FITC

产品编号： YB--9084R-FITC

产品价格： null

产品产地： 中国/美国

品牌商标： Ybscience

更新时间： 2023-08-17T10:29:50

使用范围： 科研使用

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 Anti-FBXW12/FITC Conjugated抗体

产品编号 YB-9084R-FITC
英文名称 Anti-FBXW12/FITC
中文名称 FITC标记的FBXW12蛋白抗体
别    名 F box and WD 40 domain containing protein 12; F box and WD 40 domain protein 12; F box and WD repeat domain containing 12; F box and WD40 repeat containing protein; F box only protein 35; F box/WD repeat containing protein 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35; F-box/WD repeat-containing protein 12; Fbw12; FBW12_HUMAN; FBX12; FBXO12; FBXO35; FBXW 12; FBXW12.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  信号转导  细胞周期蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FBXW12/FBXO35
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Belonging to the F-box family of proteins, FBXO35 (F-box only protein 35), also designated F-box and WD-40 domain-containing protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously expressed at low levels in most human tissues.

Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).

Subunit:
Directly interacts with SKP1 and CUL1

Tissue Specificity:
Ubiquitously expressed

Similarity:
Contains 1 F-box domain. 
Contains 5 WD repeats. 

Database links:
UniProtKB/Swiss-Prot: Q6X9E4.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applicationS