分子量:23.2 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human SOD2, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human SOD2, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 23.2 kDa. The predicted N-terminus is Met. The reducing (R) protein migrates as 27 kDa in SDS-PAGE .

产品背景:Superoxide dismutase [Mn], mitochondrial (SOD2),a member of the iron/manganese superoxide dismutase family, can form a homotetramer and bind one manganese ion per subunit. The  expression of SOD2 is regulated by KRIT1. Mutations in SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), sporadic motor neuron disease, and cancer. Furthermore, Mn-SOD (SOD2) activity is essential to achieve optimal training-induced protection against both ischemia/reperfusion(IR)-induced cardiac arrhythmias and infarction.