GIMAP5,GTP酶IMAP家族成员5抗体

产品编号HZ-8271R
英文名称GIMAP5
中文名称GTP酶IMAP家族成员5抗体
别 名HIMAP3; IAN4; IAN4L1; IAN5; IMAP3; FLJ11296; GIMAP 5; GTPase IMAP family member 5; GTPase, IMAP family member 5; immunity-associated nucleotide 5; hIAN5; IAN 5; Immune associated nucleotide 4 like 1; Immunity associated nucleotide 4 like 1 protein; Immunity associated protein 3; GIMA5_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 t-淋巴细胞 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
GIMAP5,GTP酶IMAP家族成员5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from huam GIMAP5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GIMAP5,GTP酶IMAP家族成员5抗体PubMedPubMed
产品介绍background:
GIMAP5, also known as IAN5, IAN4L1 (immunity-associated nucleotide 4-like 1 protein), IAN4, IMAP3, HIMAP3 or IROD, is a 307 amino acid single-pass type IV membrane protein of the mitochondrial outer membrane. A member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, GIMAP5 plays a role in T-cell survival and mitochondrial integrity. GIMAP5 is highly expressed in CD4 and CD8-positive T-cells and monocytes, as well as B-lymphocyte-derived neoplasms. GIMAP5 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 7q36.1. Defects in the GIMAP5 gene are associated with systemic lupus erythematosus.

Function:
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).

Subcellular Location:
Mitochondrion outer membrane; Single-pass type IV membrane protein (By similarity). Lysosome.

Tissue Specificity:
Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.

GIMAP5,GTP酶IMAP家族成员5抗体Similarity:
Belongs to the IAN GTP-binding protein family.

Database links:
UniProtKB/Swiss-Prot: Q96F15.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.