内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Human IL-7, Tag Free (Catalog # IL7-H4219) at 10μg/mL (100 μL/well) can bind Biotinylated Human IL-7 R alpha, Fc Tag (Catalog # IL7-H82F8) with a linear range of 0.02-0.15 μg/mL.

产品背景:
Interleukin-7 receptor subunit alpha (IL-7 RA or IL7Ra) is also known as cluster of differentiation 127 (CD127). IL-7 RA is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors. IL-7 RA has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination[citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation.

产品描述:
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag). The protein has a calculated MW of 53.3 kDa. As a result of glycosylation, The protein migrates as 70-100 kDa under reducing (R) condition and 130-200 kDa under non-reducing (NR) condition on SDS-PAGE gel.