Delta Catenin,δ连环蛋白/δ连环素/δ链接素（δ-catenin）抗体

产品编号HZ-7000R
英文名称Delta Catenin
中文名称δ连环蛋白/δ连环素/δ链接素（δ-catenin）抗体
别 名delta 1 Catenin; Cadherin associated Src substrate; Cadherin-associated Src substrate; CAS; Catenin (cadherin associated protein) delta 1; Catenin delta 1; Catenin delta-1; CTND1_HUMAN; CTNND 1; CTNND; CTNND1; KIAA0384; p120; P120 CAS; p120 catenin; P120 CTN; p120(cas); p120(ctn); P120CAS; P120CTN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 干细胞 细胞骨架 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
Delta Catenin,δ连环蛋白/δ连环素/δ链接素（δ-catenin）抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量106kDa
细胞定位细胞核 细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Delta Catenin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Delta Catenin,δ连环蛋白/δ连环素/δ链接素（δ-catenin）抗体PubMedPubMed
产品介绍background:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Function:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Subunit:
Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.

Delta Catenin,δ连环蛋白/δ连环素/δ链接素（δ-catenin）抗体Subcellular Location:
Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.

Tissue Specificity:
Expressed in vascular endothelium.

Post-translational modifications:
Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.

Similarity:
Belongs to the beta-catenin family.
Contains 10 ARM repeats.

Database links:
Entrez Gene: 1500 Human
Entrez Gene: 12388 Mouse
Entrez Gene: 311163 Rat
Omim: 601045 Human
SwissProt: O60716 Human
SwissProt: P30999 Mouse
Unigene: 166011 Human
Unigene: 35738 Mouse
Unigene: 9435 Rat

Delta Catenin,δ连环蛋白/δ连环素/δ链接素（δ-catenin）抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

p120-连环素也可能参与细胞侵入力调节.