ELMO3,ELMO3蛋白抗体

产品编号HZ-14566R
英文名称ELMO3
中文名称ELMO3蛋白抗体
别 名CED 12; Ced 12 homolog 3; CED12; ELMO 3; ELMO3; ELMO3_HUMAN; Engulfment and cell motility 3; Engulfment and cell motility protein 3; FLJ13824.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞凋亡 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig,
ELMO3,ELMO3蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量69kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ELMO3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ELMO3,ELMO3蛋白抗体PubMedPubMed
产品介绍background:
Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase mediated tyrosine phosphorylation of ELMO1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The RhoG-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK180 and Crk II and may be required in complex with DOCK180 to activate Rac/Rho small GTPases.

Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Subcellular Location:
Cytoplasm.

Tissue Specificity:

Post-translational modifications:

ELMO3,ELMO3蛋白抗体Similarity:
Contains 1 ELMO domain.
Contains 1 PH domain.

Gene ID:
79767

Database links:
Entrez Gene: 79767 Human
Entrez Gene: 525427 Cow
Entrez Gene: 489763 Dog
Entrez Gene: 100734823 Guinea pig
Entrez Gene: 100065878 Horse
Entrez Gene: 234683 Mouse
Entrez Gene: 100522492 Pig
Entrez Gene: 291962 Rat
Omim: 606422 Human
SwissProt: A6QR40 Cow
SwissProt: Q96BJ8 Human
SwissProt: Q8BYZ7 Mouse
SwissProt: Q499U2 Rat
Unigene: 377416 Human
Unigene: 237966 Mouse
Unigene: 151249 Rat

ELMO3,ELMO3蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.