SNIP1,Smad核相互作用蛋白1抗体

产品编号HZ-11260R
英文名称SNIP1
中文名称Smad核相互作用蛋白1抗体
别 名FHA domain-containing protein SNIP1; FLJ12553; Smad nuclear interacting protein (Smad nuclear interacting); Smad nuclear interacting protein; Smad nuclear-interacting protein 1; SNIP1 (Smad nuclear interacting protein); SNIP1; SNIP1_HUMAN; Splicing factor arginine/serine rich 4 (Pre mRNA splicing factor SRP75).
说 明 书0.1ml 0.2ml
研究领域信号转导 生长因子和激素 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
SNIP1,Smad核相互作用蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SNIP1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SNIP1,Smad核相互作用蛋白1抗体PubMedPubMed
产品介绍background:
Members of the transforming growth factor-beta (TGF-Beta) superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-Beta family ligands are mediated by Smad proteins. The Smad nuclear interacting protein (SNIP1) contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 potently inhibits the activity of NF-kappa B, which binds the C/H1 domain of CBP/p300, by competing for the binding site. SNIP1 is also thought to induce expression of Cyclin D1 to promote cellular proliferation. SNIP1 is ubiquitously expressed with high expression in heart and skeletal muscle.

Function:
Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis.

Subunit:
Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN.

Subcellular Location:
Nucleus.

Tissue Specificity:
Tissue specificityUbiquitous, with highest expression in heart and skeletal muscle.

Post-translational modifications:
Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex.

DISEASE:
Defects in SNIP1 are the cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED) [MIM:614501]. A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period.

SNIP1,Smad核相互作用蛋白1抗体Similarity:
Contains 1 FHA domain.

Database links:
UniProtKB/Swiss-Prot: Q8TAD8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.