AVEN,细胞死亡调节蛋白抗体

产品编号HZ-2438R
英文名称AVEN
中文名称细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂)
别 名1700013A01Rik; 1700056A21Rik; mAven L; mAven S; MGC124011; Apoptosis caspase activation inhibitor; Cell death regulator Aven; OTTMUSP00000016129; PDCD12; Programmed cell death 12; RP23-52C15.2; AVEN_HUMAN
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞凋亡
抗体来源Rabbit
AVEN,细胞死亡调节蛋白抗体克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AVEN
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AVEN,细胞死亡调节蛋白抗体PubMedPubMed
产品介绍background:
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients.

Function:
Protects against apoptosis mediated by Apaf-1

Subunit:
Binds Apaf-1, BCL-2 and BAD (Bcl-xl)

Subcellular Location:
Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes.

Tissue Specificity:
Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.

Gene ID:
57099

AVEN,细胞死亡调节蛋白抗体Database links:
Entrez Gene: 57099 Human
Entrez Gene: 74268 Mouse
Entrez Gene: 311299 Rat
Omim: 605265 Human
SwissProt: Q9NQS1 Human
SwissProt: Q9D9K3 Mouse
Unigene: 555966 Human
Unigene: 315125 Mouse
Unigene: 436657 Mouse
Unigene: 145049 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.