IKBKAP polyclonal antibody
产品名称： IKBKAP polyclonal antibody
英文名称： IKBKAP polyclonal antibody
产品编号： PAB12857
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of IKBKAP.
- Immunogen:
- A synthetic peptide corresponding to C-terminus 16 amino acids of human IKBKAP.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Purification and characterization of the human elongator complex.
Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ.J Biol Chem. 2002 Jan 25;277(4):3047-52. Epub 2001 Nov 19.
- 2.
- Familial dysautonomia is caused by mutations of the IKAP gene.
Anderson SL, Coli R, Daly IW, Kichula EA, Rork MJ, Volpi SA, Ekstein J, Rubin BY.Am J Hum Genet. 2001 Mar;68(3):753-8. Epub 2001 Jan 22.
- 3.
- IKAP is a scaffold protein of the IkappaB kinase complex.
Cohen L, Henzel WJ, Baeuerle PA.Nature. 1998 Sep 17;395(6699):292-6.
- Entrez GeneID:
- 8518
- Protein Accession#:
- AAC64258
- Gene Name:
- IKBKAP
- Gene Alias:
- DKFZp781H1425,DYS,ELP1,FD,FLJ12497,IKAP,IKI3,TOT1
- Gene Description:
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq
- Other Designations:
- OTTHUMP00000021869,OTTHUMP00000063889
- Related Disease
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Bronchial Hyperreactivity
- Bronchiolitis, Viral
- Cardiovascular Diseases
- Cystic fibrosis
- Dermatitis, Atopic
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Dysautonomia, Familial
- Edema
- Gaucher disease
- Genetic Diseases, Inborn
- Genetic Predisposition to Disease
- Heart Defects, Congenital
- Hereditary Sensory and Autonomic Neuropathies
- Hirschsprung Disease
- Hypersensitivity, Immediate