CACNB4,L型电压依赖型钙通道β4抗体

产品编号HZ-11983R
英文名称CACNB4
中文名称L型电压依赖型钙通道β4抗体
别 名CAB4; L-type Ca++ CPβ4; CACB4_HUMAN; Cacnb4; CACNLB4; Calcium channel voltage dependent beta 4 subunit; Calcium channel voltage dependent subunit beta 4; Calcium channel voltage-dependent subunit beta 4; Dihydropyridine sensitive L type calcium channel beta 4 subunit; EA5; EIG9; EJM; EJM4; Voltage-dependent L-type calcium channel subunit beta-4.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
CACNB4,L型电压依赖型钙通道β4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量58kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CACNB4/L-type Ca++ CPβ4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CACNB4,L型电压依赖型钙通道β4抗体PubMedPubMed
产品介绍background:
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1-Beta 4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. L-type Ca++ CP Beta 4, also known as CACNB4 (Calcium channel voltage-dependent subunit beta 4), CACNLB4 or CAB4, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, L-type Ca++ CP Beta 4 increases the peak calcium current in voltage-dependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of L-type Ca++ CP Beta4 exist due to alternative splicing events.

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Subunit:
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG.

Subcellular Location:

Tissue Specificity:
Expressed predominantly in the cerebellum and kidney.

CACNB4,L型电压依赖型钙通道β4抗体DISEASE:
Genetic variations in CACNB4 are the cause of susceptibility to idiopathic generalized epilepsy type 9 (IGE9) [MIM:607682]. IGE9 is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
Genetic variations in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6) [MIM:607682]. EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.

Similarity:
Belongs to the calcium channel beta subunit family.
Contains 1 SH3 domain.

Database links:
Entrez Gene: 785 Human
Entrez Gene: 12298 Mouse
Entrez Gene: 58942 Rat
Omim: 601949 Human
SwissProt: O00305 Human
SwissProt: Q8R0S4 Mouse
Unigene: 120725 Human
Unigene: 330223 Mouse
Unigene: 472778 Mouse
Unigene: 9863 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.