FITC标记的多药耐药蛋白/P-糖蛋白抗体(C端)
产品名称： FITC标记的多药耐药蛋白/P-糖蛋白抗体(C端)
英文名称： Anti-MDR1/P Glycoprotein/FITC
产品编号： HZ-1468R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-MDR1/P Glycoprotein/FITC Conjugated antibody
FITC标记的多药耐药蛋白/P-糖蛋白抗体(C端)
| 英文名称Anti-MDR1/P Glycoprotein/FITC中文名称FITC标记的多药耐药蛋白/P-糖蛋白抗体(C端)别 名ABC20; ABCB1; ATP binding cassette, sub family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 研究领域肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 糖蛋白 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, 产品应用Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量141kDa细胞定位细胞膜 性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human MDR1亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas. Function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Subunit: Interacts with PSMB5. Subcellular Location: Cell membrane; Multi-pass membrane protein (By similarity). Tissue Specificity: Expressed in liver, kidney, small intestine and brain. DISEASE: Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases. Similarity: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. Database links: Entrez Gene: 5243 Human Entrez Gene: 18669 Mouse Entrez Gene: 170913 Rat Entrez Gene: 24646 Rat Omim: 171050 Human SwissProt: P08183 Human SwissProt: P06795 Mouse SwissProt: P43245 Rat Unigene: 489033 Human Unigene: 144554 Rat Unigene: 154810 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 信号传导（Signaling Intermediates） |
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P糖蛋白是MDR1基因的产物，在不同非恶性细胞中表达，典型地是具有分泌和排泄功能的细胞。它被假定为具有ATP依赖性的药物外排泵，具有广泛的底物特异性。P糖蛋白在肾脏（近端小管）、肝脏（胆小管）、肾上腺和肠中表达最高，提示P糖蛋白的主要作用是生理代谢物和摄取的化学物质正常分泌到胆汁、尿液和肠道。肠道的内脏。在多药耐药细胞系和结肠、子宫内膜、卵巢和乳腺肿瘤以及肉瘤和白血病/淋巴瘤中也报告了P糖蛋白水平的升高。