EIF1AD,EIF1AD蛋白抗体

产品编号HZ-14531R
英文名称EIF1AD
中文名称EIF1AD蛋白抗体
别 名EIF1A_HUMAN; EIF1AD; Eukaryotic translation initiation factor 1A domain containing; Eukaryotic translation initiation factor 1A domain containing protein; Eukaryotic translation initiation factor 1A domain-containing protein; Haponin; Probable RNA binding protein EIF1AD; Probable RNA-binding protein EIF1AD.
说 明 书0.1ml 0.2ml
研究领域细胞生物 转运蛋白 新陈代谢 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Cynomolgus Monkey
EIF1AD,EIF1AD蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EIF1AD
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EIF1AD,EIF1AD蛋白抗体PubMedPubMed
产品介绍background:
eIF1AD is a 165 amino acid protein that belongs to the eIF1AD family and contains one S1-like domain. eIF1AD localizes to nucleus and is expressed in the glioblastoma cell line U-87 MG, the embryonic kidney cell line HEK-293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562. eIF1AD interacts with GAPDH and may function to reduce cell proliferation. The gene encoding eIF1AD maps to human chromosome 11q13.1. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in chromosome 11.

Function:
Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

Subunit:
Interacts with GAPDH and STAT1.

Subcellular Location:
Nucleus.

EIF1AD,EIF1AD蛋白抗体Tissue Specificity:
Expressed in the glioblastoma cell line U-87MG, the embryonic kidney cell line HEK-293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562.

Similarity:
Belongs to the EIF1AD family.
Contains 1 S1-like domain.

Gene ID:
84285

Database links:
Entrez Gene: 84285 Human
Entrez Gene: 615726 Cow
Entrez Gene: 69860 Mouse
Entrez Gene: 293673 Rat
SwissProt: Q58CY2 Cow
SwissProt: Q4R354 Cynomolgus Monkey
SwissProt: Q8N9N8 Human
SwissProt: Q3THJ3 Mouse
SwissProt: Q5RKI6 Rat
Unigene: 425178 Human
Unigene: 299167 Mouse
Unigene: 4163 Rat

EIF1AD,EIF1AD蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.