CAPS1,钙依赖分泌激活蛋白1抗体

产品编号HZ-11812R
英文名称CAPS1
中文名称钙依赖分泌激活蛋白1抗体
别 名Cadps; CADPS1; Calcium dependent secretion activator 1; Calcium-dependent activator protein for secretion 1; Calcium-dependent secretion activator 1; Caps; CAPS-1; rCAPS; CAPS1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
CAPS1,钙依赖分泌激活蛋白1抗体产品应用IHC-F=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量153kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CAPS1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CAPS1,钙依赖分泌激活蛋白1抗体PubMedPubMed
产品介绍background:
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

Function:
CAPS1 (Ca2+-dependent activator protein for secretion) belongs to the CAPS/Cadps family which consists of two members, CAPS1 and CAPS2. The CAPS family proteins are involved in the secretion of different secretory substances in developing and postnatal brains. In addition CAPS1 regulates catecholamine release from neuroendocrine cells and is expressed predominantly in the brain.

Subunit:
Homodimer. Interacts with RASL10B. Interacts with the dopamine receptor DRD2.

CAPS1,钙依赖分泌激活蛋白1抗体Subcellular Location:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2.

Tissue Specificity:
Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord.

Similarity:
Contains 1 C2 domain.
Contains 1 MHD1 (MUNC13 homology domain 1) domain.
Contains 1 PH domain.

Gene ID:
8618

Database links:
Entrez Gene: 8618 Human
Entrez Gene: 27062 Mouse
Entrez Gene: 26989 Rat
Omim: 604667 Human
SwissProt: Q9ULU8 Human
SwissProt: Q80TJ1 Mouse
SwissProt: Q62717 Rat
Unigene: 260881 Mouse
Unigene: 88197 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.