EphA3,酪氨酸蛋白激酶受体A3抗体

产品编号HZ-7032R
英文名称EphA3
中文名称酪氨酸蛋白激酶受体A3抗体
别 名EK4; End3; Eph receptor A3; EPH-like kinase 4; EPH-like tyrosine kinase 1; EphA3; Ephrin receptor EphA3; Ephrin type-A receptor 3; ETK 1; ETK; ETK1; HEK 4; HEK; Hek4; Human embryo kinase; Mek4; MGC109882; Receptor tyrosine kinase HEK; Tyro 4; Tyro4; Tyrosine protein kinase receptor ETK 1; Tyrosine-protein kinase TYRO4; AW492086; Cek4; EC 2.7.10.1; EPHA3_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 细胞生物 神经生物学 信号转导 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
EphA3,酪氨酸蛋白激酶受体A3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-300 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量106kDa
细胞定位细胞膜 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EphA3/Eph receptor A3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EphA3,酪氨酸蛋白激酶受体A3抗体PubMedPubMed
产品介绍background:
EphA3 is a member of the Ephrin (Eph) family. The Ephrins and Eph-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the Ephrin A (EphA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the Ephrin B (EphB) class, which are transmembrane proteins. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats.

Function:
Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.

Subunit:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.

Subcellular Location:
Secreted and Cell membrane.

Tissue Specificity:
Widely expressed. Highest level in placenta.

Post-translational modifications:
Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1.

DISEASE:
Defects in EPHA3 may be a cause of colorectal cancer (CRC)

EphA3,酪氨酸蛋白激酶受体A3抗体Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.

Gene ID:
2042

Database links:
Entrez Gene: 2042 Human
Entrez Gene: 13837 Mouse
Entrez Gene: 29210 Rat
Omim: 179611 Human
SwissProt: P29320 Human
SwissProt: P29319 Mouse
SwissProt: O08680 Rat
Unigene: 123642 Human
Unigene: 1977 Mouse
Unigene: 10713 Rat

EphA3,酪氨酸蛋白激酶受体A3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.