Anti-FAS(C-term) Monoclonal Antibody

品牌：Solarbio | 货号：K000037M

英文名称 Anti-FAS(C-term) Monoclonal Antibody
宿主 Mouse
别名 ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6
应用 WB
稀释比例 WB 1:1000.
交叉反应 Human
蛋白分子量 45kDa
Gene ID 355
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG1
免疫原 Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli.
性状 液体
Public Immunogen Range Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli.
Subcellular Locations Cell membrane Secreted Single-pass type I membrane protein
Swiss Prot P25445
克隆号 4C3-G7-B7-H5
克隆类型 Monoclonal Antibody
背景资料 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

英文名称	Anti-FAS(C-term) Monoclonal Antibody
宿主	Mouse
别名	ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6
应用	WB
稀释比例	WB 1:1000.
交叉反应	Human
蛋白分子量	45kDa
Gene ID	355
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli.
Subcellular Locations	Cell membrane Secreted Single-pass type I membrane protein
Swiss Prot	P25445
克隆号	4C3-G7-B7-H5
克隆类型	Monoclonal Antibody
背景资料	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.