TNFAIP8L2,肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体

产品编号HZ-11035R
英文名称TNFAIP8L2
中文名称肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体
别 名Tumor necrosis factor alpha-induced protein 8-like protein 2; Inflammation factor protein 20; TIPE2; TIPE 2; TIPE-2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; TNFAIP8L2; TP8L2_HUMAN; Tumor necrosis factor alpha-induced protein 8-like protein 2; AW610835; FLJ23467.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 细胞凋亡
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
TNFAIP8L2,肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TNFAIP8L2/TIPE2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
TNFAIP8L2,肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体PubMedPubMed
产品介绍background:
TNF Alpha-IP 8L2 (tumor necrosis factor, alpha-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNF Alpha-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNF?IP 8L2 functions as a negative regulator of T-cell receptor function and is thought to promote Fas-induced apoptosis. The gene encoding TNF?IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

Function:
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.

TNFAIP8L2,肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体Subunit:
May interact with CASP8; however, such result is unclearsince PubMed:19079267 could not reproduce the interaction withCASP8.

Tissue Specificity:
Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin

Similarity:
Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.

Database links:
Entrez Gene: 79626 Human
Entrez Gene: 69769 Mouse
Entrez Gene: 100328663 Rabbit
Entrez Gene: 310663 Rat
Entrez Gene: 510652 Cow
Omim: 612112 Human
SwissProt: A9X192 Baboon
SwissProt: Q3ZBK5 Cow
SwissProt: Q6P589 Human
SwissProt: Q9D8Y7 Mouse
SwissProt: B7NZC7 Rabbit
SwissProt: Q6AYJ8 Rat
Unigene: 709522 Human

TNFAIP8L2,肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Tissue/cell: rat spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-TNFAIP8L2 Polyclonal Antibody, Unconjugated(HZ-11035R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining