H3N2 hemagglutinin,流感病毒H3N2血凝素抗体

产品编号HZ-2137R
英文名称H3N2 hemagglutinin
中文名称流感病毒H3N2血凝素抗体
别 名HA; Influenza A virus H3N2; hemagglutinin; H3N2; H3N2 hemagglutinin; HEMA_I68A0; Hemagglutinin HA1 chain; Hemagglutinin HA2 chain.
说 明 书0.1ml 0.2ml
研究领域免疫学 信号转导 细菌及病毒
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Influenza A virus H3N2
H3N2 hemagglutinin,流感病毒H3N2血凝素抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量63kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from H3N2 hemagglutinin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
H3N2 hemagglutinin,流感病毒H3N2血凝素抗体PubMedPubMed
产品介绍background:
Hemagglutinin (HA) is a class I viral fusion protein from Influenza virus. It is a major glycoprotein, comprising over 80% of the envelope proteins present in the virus particle. HA binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell, and is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. The extent of infection into host organism is determined by HA. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoproteases secreted by the bronchial epithelial cells. The HA protein is a homotrimer of disulfide-linked HA1-HA2. It also plays a major role in the determination of host range restriction and virulence. Genetic variation of hemagglutinin and/or neuraminidase genes results in the emergence of new influenza strains.

Function:
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Subunit:
Homotrimer of disulfide-linked HA1-HA2.

Subcellular Location:
Cell membrane; apical cell membrane; single-pass type I membrane protein.

Post-translational modifications:
In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells. Palmitoylated (By similarity).

H3N2 hemagglutinin,流感病毒H3N2血凝素抗体Similarity:
Belongs to the influenza viruses hemagglutinin family.

Database links:
UniProtKB/Swiss-Prot: P03437.1
GenBank: AGB84854.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.