ETV2,ETS相关蛋白71抗体

产品编号HZ-12341R
英文名称ETV2
中文名称ETS相关蛋白71抗体
别 名ER71; Ets related protein 71; ETS translocation variant 2; Ets variant gene 2; Ets-related protein 71; ETSRP71; ETV2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 干细胞 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
ETV2,ETS相关蛋白71抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from Human ETV2/ER71
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
ETV2,ETS相关蛋白71抗体PubMedPubMed
产品介绍background:
ER71 is a 341 amino acid member of the ETS protein family. Localized to the nucleus, ER71 contains one ETS DNA-binding domain which binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. The gene encoding ER71 maps to human chromosome 19, which consists of around 63 million bases with over 1,400 genes, making up over 2% of human genomic DNA. Chromosome 19 is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.

Function:
ETV2 is a member of the ETS family of transcription factors. It has been proposed that ETV2 acts downstream of BMP, notch and wnt signalling in blood and vessel specification. ER71 has also shown to be important for Flk1 expression as well as hematopoietic and vascular development.

Subunit:

Subcellular Location:
Nuclear.

ETV2,ETS相关蛋白71抗体Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.

Database links:
Entrez Gene: 2116 Human
Omim: 609358 Human
SwissProt: O00321 Human
Unigene: 194061 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.