ANKRD47,锚蛋白重复结构域47抗体

产品编号HZ-17218R
英文名称ANKRD47
中文名称锚蛋白重复结构域47抗体
别 名ANKRD47; Ankyrin repeat domain 47; Ankyrin repeat domain containing protein 47; Ankyrin repeat domain-containing protein 47; FLJ46061; KANK3; KANK3_HUMAN; Kidney ankyrin repeat containing protein 3; KN motif and ankyrin repeat domain containing protein 3; KN motif and ankyrin repeat domain-containing protein 3; KN motif and ankyrin repeat domains 3; Ng28.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
ANKRD47,锚蛋白重复结构域47抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ANKRD47
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ANKRD47,锚蛋白重复结构域47抗体PubMedPubMed
产品介绍background:
Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD47 an 840 amino acid coiled-coil protein that contains five ANK repeats and exists as two alternatively spliced isoforms. Conserved in chimpanzee, dog, cow, mouse and rat, ANKRD47 is expressed in breast, liver, lung, skeletal muscle and kidney. ANKRD47 assists in the formation of actin stress fibers and is encoded by a gene that maps to human chromosome 19p13.2. Chromosome 19 makes up over 2% of the human genome and contains approximately 63 million bases, which encode over 1,400 genes. Recognized for having the greatest gene density of all human chromosomes, chromosome 19 is linked to Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes

Function:
May be involved in the control of cytoskeleton formation by regulating actin polymerization.

Subcellular Location:

Tissue Specificity:
Strongly expressed in breast, liver, lung, skeletal muscle and kidney.

Post-translational modifications:

Similarity:
Contains 5 ANK repeats.

Gene ID:
256949

ANKRD47,锚蛋白重复结构域47抗体Database links:
Entrez Gene: 256949 Human
Entrez Gene: 80880 Mouse
Entrez Gene: 366848 Rat
Omim: 614611 Human
SwissProt: Q6NY19 Human
SwissProt: Q9Z1P7 Mouse
Unigene: 322473 Human
Unigene: 196330 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.