GCLM monoclonal antibody (M01), clone 2B8
产品名称： GCLM monoclonal antibody (M01), clone 2B8
英文名称： GCLM monoclonal antibody (M01), clone 2B8
产品编号： H00002730-M01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a full length recombinant GCLM.
- Immunogen:
- GCLM (AAH41809, 1 a.a. ~ 274 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSGASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (55.88 KDa) .
- MSDS:
Download
- Publication Reference
- 1.
- Protection against 2-chloroethyl ethyl sulfide (CEES) - Induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway.
Abel EL, Bubel JD, Simper MS, Powell L, McClellan SA, Andreeff M, Macleod MC, Digiovanni J.Toxicol Appl Pharmacol. 2011 Jun 23. [Epub ahead of print]
- 2.
- Molecular and Functional Characterization of Gastrula Organizer Cells Derived from Human Embryonic Stem Cells.
Sharon N, Mor I, Golan-Lev T, Fainsod A, Benvenisty N.Stem Cells. 2011 Feb 15. doi: 10.1002/stem.621. [Epub ahead of print]
- 3.
- Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease.
Hardwick RN, Fisher CD, Canet MJ, Lake AD, Cherrington NJ.Drug Metab Dispos. 2010 Dec;38(12):2293-301. Epub 2010 Aug 30.
- 4.
- Induction of Antioxidant Enzymes by Curcumin and Its Analogues in Human Islets: Implications in Transplantation.
Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S.Pancreas. 2009 May;38(4):454-60.
- Applications
- Western Blot (Cell lysate)
- GCLM monoclonal antibody (M01), clone 2B8 Western Blot analysis of GCLM expression in HeLa ( Cat # L013V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged GCLM is approximately 1ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 2730
- GeneBank Accession#:
- BC041809
- Protein Accession#:
- AAH41809
- Gene Name:
- GCLM
- Gene Alias:
- GLCLR
- Gene Description:
- glutamate-cysteine ligase, modifier subunit
- Omim ID:
- 601176
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq
- Other Designations:
- GSC light chain,OTTHUMP00000012299,gamma-glutamylcysteine synthetase,glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD),glutamate-cysteine ligase regulatory protein
- Gene Pathway
- Related Disease
- Amphetamine-Related Disorders
- Arsenic Poisoning
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Berylliosis
- Bipolar Disorder
- Cardiovascular Diseases
- Carotid Artery Diseases
- Cerebral Infarction
- Chronic Disease
- Coronary Artery Disease
- Coronary Disease
- Dementia, Vascular
- Diabetes Mellitus, Type 2
- Disease Progression
- DNA Damage
- Edema