CENTG3,CENTG3蛋白抗体

产品编号HZ-13846R
英文名称CENTG3
中文名称CENTG3蛋白抗体
别 名AGAP-3; Agap3; AGAP3_HUMAN; ANK repeat and PH domain-containing protein 3; Arf GAP with GTPase, ANK repeat and PH domain containing protein 3; Arf-GAP with GTPase; ArfGAP with GTPase domain, ankyrin repeat and PH domain; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; centaurin gamma 3; Centaurin-gamma-3; CENTG3; Cnt-g3; CRAG; CRAM-associated GTPase; CRMP (collapsin response mediator protein) associated; FLJ16146; FLJ34452; MR1-interacting protein; MRIP-1; MRIP1; OTTHUMP00000213333; OTTHUMP00000213334; OTTHUMP00000213335; OTTHUMP00000213336.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
CENTG3,CENTG3蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量95kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CENTG3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CENTG3,CENTG3蛋白抗体PubMedPubMed
产品介绍background:
ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP OTTHUMP00000213337; domain, five PH domains, one Ras-associating domain, one Rho-GAP domain and one SAM (sterile a motif) domain.

Function:
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.

Subcellular Location:
Cytoplasm. In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the centaurin gamma-like family.
Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.
Contains 1 PH domain.

CENTG3,CENTG3蛋白抗体Gene ID:
116988

Database links:
Entrez Gene: 116988 Human
Entrez Gene: 213990 Mouse
Entrez Gene: 362300 Rat
SwissProt: Q96P47 Human
SwissProt: Q8VHH5 Mouse
Unigene: 647075 Human
Unigene: 250703 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.