CHSY2/3,硫酸软骨素酶2、3抗体

产品编号HZ-13944R
英文名称CHSY2/3
中文名称硫酸软骨素酶2、3抗体
别 名Carbohydrate synthase 2; Chondroitin glucuronyltransferase 3; Chondroitin sulfate synthase 3; Chondroitin synthase 2; CHSS3_HUMAN; ChSy-2; CHSY2; Chsy3; CSS3; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3; N-acetylgalactosaminyltransferase 3.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 生长因子和激素 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
CHSY2/3,硫酸软骨素酶2、3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量100kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CHSY2/3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CHSY2/3,硫酸软骨素酶2、3抗体PubMedPubMed
产品介绍background:
CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008
Chondroitin sulfate synthases (CHSYs) synthesize chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to various of core protein families and regulate many biologic processes, including extracellular matrix deposition, cell proliferation and recognition, and morphogenesis. The CHSY family includes CHSY1, CHSY2 and CHSY3. CHSY1 and CHSY3 display both glucuronyltransferase and N-acetylgalactosaminyltransferase activities, while CHSY2 is required for chondroitin polymerizing activity. CHSY2 localizes to the Golgi apparatus and is expressed ubiquitously, with highest expression observed in the pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, small intestine and placenta.

Function:
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.

Subunit:

Subcellular Location:
Golgi apparatus; Golgi stack membrane.

Tissue Specificity:
Detected at low levels in brain, cerebral cortex, uterus and small intestine.

Similarity:
Belongs to the chondroitin N-acetylgalactosaminyltransferase family.

Gene ID:
337876

Database links:
Entrez Gene: 337876 Human
Omim: 609963 Human
SwissProt: Q70JA7 Human
Unigene: 213137 Human

CHSY2/3,硫酸软骨素酶2、3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.