FITC标记的Fas相关磷酸酶1抗体
产品名称： FITC标记的Fas相关磷酸酶1抗体
英文名称： Anti-FAP1/FITC
产品编号： HZ-5760R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FAP1/FITC Conjugated antibody
FITC标记的Fas相关磷酸酶1抗体
| 英文名称 | Anti-FAP1/FITC |
| 中文名称 | FITC标记的Fas相关磷酸酶1抗体 |
| 别 名 | APO1/CD95 (Fas) associated phosphatase; Fas associated phosphatase 1; Protein tyrosine phosphatase non receptor type 13; PTP BAS; PTP BL; DKFZp686J1497; FAP 1; FAP-1; FAP1; Fas associated protein tyrosine phosphatase 1; Fas-associated protein-tyrosine phosphatase 1; HGNC:9646; hPTPE1; PNP 1; PNP1; Protein tyrosine phosphatase 1 Fas associated; protein tyrosine phosphatase 1E; Protein tyrosine phosphatase nonreceptor type 13; Protein tyrosine phosphatase PTPL1; Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; PTP E1; PTP-E1; PTP1E; PTPL 1; PTPL1; PTPLE; PTPN 13; PTPN13; Tyrosine protein phosphatase non receptor type 13. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 273kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FAP1/PTPN13 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Subunit: Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus). Subcellular Location: Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. Tissue Specificity: Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 KIND domain. Contains 5 PDZ (DHR) domains. Contains 1 tyrosine-protein phosphatase domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PTPN13是蛋白酪氨酸磷酸酶（PTP）家族的成员。PTPs已知是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该PTP是一种在C-末端具有PTP结构域的大蛋白，以及多个非催化结构域，其包括与细胞骨架相关蛋白的带4.1超家族相似的结构域、由五个PDZ结构域组成的区域和亮氨酸拉链基序。发现该PTP通过PDZ结构域与Fas受体、i-KAPPA-B-α相互作用，并提示其在Fas介导的程序性细胞死亡中的作用。该PTP还与GTP酶激活蛋白相互作用，从而起到调节Rho信号通路的作用。