FITC标记的锌指蛋白346抗体
产品名称： FITC标记的锌指蛋白346抗体
英文名称： Anti-ZNF346/FITC
产品编号： HZ-12235R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZNF346/FITC Conjugated antibody
FITC标记的锌指蛋白346抗体
| 英文名称 | Anti-ZNF346/FITC |
| 中文名称 | FITC标记的锌指蛋白346抗体 |
| 别 名 | DKFZp547M223; Double stranded RNA binding zinc finger protein; Double stranded RNA binding zinc finger protein JAZ; JAZ; Just another zinc finger protein; Zfp346; Zinc finger protein 346; ZN346_HUMAN; Znf346. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human ZNF346 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF346 (Zinc finger protein 346), also known as JAZ (Just another zinc finger protein), is a 294 amino acid protein that contains four matrin-type zinc fingers. The matrin-type zinc finger, which is very similar in structure to the classical DNA-binding C2H2 zinc finger, was first identified in the protein matrin-3. The matrin-type zinc finger has also been identified in several spliceosome RNA-binding proteins. Two isoforms exists due to alternate splicing events. Function: Binds to dsRNA and DNA. Subunit: Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner. Subcellular Location: Nucleus Cytoplasm. Similarity: Contains 4 matrin-type zinc fingers. Database links: Entrez Gene: 23567 Human Entrez Gene: 26919 Mouse Entrez Gene: 306765 Rat Omim: 605308 Human SwissProt: Q9UL40 Human SwissProt: Q9R0B7 Mouse Unigene: 484259 Human Unigene: 671568 Human Unigene: 22795 Mouse Unigene: 17764 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
锌指蛋白含有DNA结合结构域，具有多种功能，其中大多数包含某种形式的转录激活或抑制。ZNF346(锌指蛋白346)，也称为JAZ(只是另一种锌指蛋白)，是一种294个氨基酸的蛋白质，含有四个苦参素型锌指。首先在蛋白matrin-3中鉴定出与经典的DNA结合C2H2锌指结构非常相似的matrin型锌指。在几个剪接体RNA结合蛋白中也鉴定出了苦参素型锌指。由于交替剪接事件存在两种异构体。