骨生化标志物ELISA试剂盒详细介绍：

一.Rat C-Terminal PTH ELISA Kit   INTENDED USE

This kit intended for research use only in the determination of rat CTerminalPTH in serum, plasma or cell culture media.

二.Rat C-Terminal PTH ELISA Kit    INTRODUCTION

Rat intact parathyroid hormone (PTH) is an 84 amino acid polypeptide produced by the parathyroid gland with its biological activity residing in the N-Terminal region of the peptide. PTH plays an important role in maintaining the concentration of ionized calcium within the limits needed to achieve normal metabolic functions. When serum calcium levels are decreased the parathyroid gland increases secretion from skeletal reserves into the circulation. When levels of serum calcium are increased the secretion of PTH is reduced. PTH undergoes extensive in-vivo catabolism producing numerous midregion and C-terminal fragments. These fragments have a much longer
half-life in circulation than intact PTH and accumulate to high levels. Since PTH fragments are cleared from circulation by the kidney highly elevated levels can be seen with renal insufficiency.
The similarities between rat and human physiology relative to calcium metabolism make the rat an excellent live-animal model for studying skeletal disease and in the pre-clinical evaluation of pharmacologic agents that may alter bone remodeling. Rat C-Terminal PTH ELISA Kit          

The determination of rat PTH with this kit can provide a precise and sensitive assessment of changes in bone and mineral metabolism.