分子量:59.6 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Mesothelin (aa 296-580), Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5

生物活性:

产品特性:Human Mesothelin (aa 296-580), Fc Tag is fused with a human IgG1 Fc tag at the N-terminus, and has a calculated MW of 59.6 kDa. The predicted N-terminus is Glu. As a result of glycosylation, the reducing (R) protein migrates as 60-68 kDa, and the non-reducing (NR) protein migrates as 120-130 kDa in SDS-PAGE .

产品背景:Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.