AARE,氧化蛋白质水解酶

产品编号HZ-5983R
英文名称AARE
中文名称氧化蛋白质水解酶
别 名AARE; ACPH; Acyl peptide hydrolase; Acylamino acid releasing enzyme; Acylaminoacyl peptidase; APEH; APH; D3F15S2; D3S48E; DNF15S2; N acylaminoacyl peptide hydrolase; OPH; Oxidized protein hydrolase; ACPH_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
AARE,氧化蛋白质水解酶产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AARE
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AARE,氧化蛋白质水解酶PubMedPubMed
产品介绍background:
AARE (Acylamino-acid-releasing enzyme) is also known as Acyl-peptide hydrolase. It catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus corresponding to the protein are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.

Function:
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

Subunit:
Interacts with SUV420H1, SUV420H2 and USP4

Subcellular Location:
Nucleus.

Similarity:
Belongs to the retinoblastoma protein (RB) family.

Gene ID:
327

Database links:
Entrez Gene: 327 Human
Entrez Gene: 235606 Mouse
Entrez Gene: 24206 Rat
GenBank: 33875348 Human
Omim: 102645 Human
SwissProt: P13798 Human
SwissProt: Q8R146 Mouse
SwissProt: P13676 Rat
Unigene: 517969 Human
Unigene: 219639 Mouse
Unigene: 11057 Rat

AARE,氧化蛋白质水解酶Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.