FITC标记的线粒体内膜转位酶8B
产品名称： FITC标记的线粒体内膜转位酶8B
英文名称： Anti-TIMM8B/FITC
产品编号： HZ-23056R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TIMM8B/FITC Conjugated antibody
FITC标记的线粒体内膜转位酶8B
| 英文名称 | Anti-TIMM8B/FITC |
| 中文名称 | FITC标记的线粒体内膜转位酶8B |
| 别 名 | DDP2; Deafness dystonia protein 2; FLJ21744; MGC102866; MGC117373; Mitochondrial import inner membrane translocase subunit Tim8 B; Small zinc finger like protein DDP2; TIM8B; ranslocase of inner mitochondrial membrane 8 homolog B (yeast); Translocase of inner mitochondrial membrane 8 homolog b; |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 9kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIMM8B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009] Function: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Subunit: Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity). Subcellular Location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Tissue Specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. Similarity: Belongs to the small Tim family. Database links: Entrez Gene: 26521 Human Entrez Gene: 30057 Mouse Entrez Gene: 64372 Rat Omim: 606659 Human SwissProt: Q9Y5J9 Human SwissProt: P62077 Mouse SwissProt: P62078 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码一个与酵母Tim线粒体导入蛋白相似的蛋白家族成员。该基因由核基因编码，并被转运到线粒体的膜间空间。当形成复合物时，这些蛋白质引导跨膜蛋白穿过线粒体膜间空间，然后将它们加入线粒体内膜。该基因与琥珀酸脱氢酶D亚基(SDHD)相邻，其中在遗传性副神经节瘤家族的受影响成员中发现了突变。