BTN2A2,嗜乳脂蛋白亚家族2成员A2抗体

产品编号HZ-7700R
英文名称BTN2A2
中文名称嗜乳脂蛋白亚家族2成员A2抗体
别 名BT2A2_HUMAN; BTF2; BTN2A2; butyrophilin 2; Butyrophilin subfamily 2 member A2.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
BTN2A2,嗜乳脂蛋白亚家族2成员A2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BTN2A2 (141-180aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BTN2A2,嗜乳脂蛋白亚家族2成员A2抗体PubMedPubMed
产品介绍background:
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

Function:
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

Subunit:

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.

Post-translational modifications:
N-glycosylated

DISEASE:

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 B30.2/SPRY domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

BTN2A2,嗜乳脂蛋白亚家族2成员A2抗体Gene ID:
10385

Database links:
Entrez Gene: 10385 Human
Entrez Gene: 238555 Mouse
Entrez Gene: 306957 Rat
Omim: 613591 Human
SwissProt: Q8WVV5 Human
SwissProt: A4QPC6 Mouse
Unigene: 373938 Human
Unigene: 129668 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.