分子量:45.9 kDa

纯度:>92% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human PTP4A2, GST Tag by the LAL method.

Buffer:50 mM HEPES, 150 mM NaCl, pH7.5 

生物活性:

产品特性:Human PTP4A2, GST Tag is fused with a GST tag at the N-terminus, and has a calculated MW of 45.9 kDa. The predicted N-terminus is Met. The reducing (R) protein migrates as 46 kDa in SDS-PAGE .

产品背景:Protein tyrosine phosphatase type IVA 2 (PTP4A2),a member of the protein-tyrosine phosphatase family, is also known as Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2 (PRL-2), PRL2 and PTPCAAX2,which is ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus and over expressed in prostate tumor tissue. PTP4A2 contains one tyrosine-protein phosphatase domain. In contrast to PTP4A1 and PTP4A3, PTP4A2 does not interact with tubulin but RABGGTB.PTP4A2 stimulates progression from G1 into S phase during mitosis and promotes tumors. PTP4A2 can also inhibit geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.The acticity of PTP4A2 is inhibited by sodium orthovanadate and pentamidine.